Accelerated epigenetic ageing in congenital heart disease: the AccelerAGE study.

Tijs K Tournoy, Bo Daelman, Laurent Demulier, Robert T Brooke, Alexander Van De Bruaene, Werner Budts, Philip Moons, Julie De Backer

Department of Cardiology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium.Department of Cardiology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium. · pubmed

Paper

Abstract

Adults with congenital heart disease tend to develop both cardiac and noncardiac age-related comorbidities earlier in life than the general population, suggesting accelerated biological ageing. Epigenetic clocks estimate biological age based on DNA methylation profiles. This study investigated whether adults with congenital heart disease display accelerated epigenetic ageing and whether the degree of age acceleration relates to disease complexity.

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Research summary

Adults with congenital heart disease exhibit accelerated epigenetic ageing, which correlates with disease complexity. This study is relevant as it explores biological ageing mechanisms in a specific population, contributing to the understanding of age-related diseases.

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