Multi-omic analysis reveals Wharton's jelly mesenchymal stem cells shift the pro-inflammatory phenotype of fibroblast subpopulation to induce skin rejuvenation.

Penghong Chen, Yiqun Qiu, Jiyao Li, Dezhi Wang, Kailun Hu, Tianyang Lan, Xuefei Wang, Xiaosong Chen

Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China.Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China. · pubmed

Paper

Abstract

Skin aging is an increasingly serious clinical problem with limited treatment options. Wharton's jelly mesenchymal stem cells (WJMSCs) represent a promising regenerative strategy. However, their mechanisms of action remain to be fully elucidated through integrated multi-omics approaches.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that Wharton's jelly mesenchymal stem cells can shift the pro-inflammatory phenotype of fibroblast subpopulations to induce skin rejuvenation. This research is relevant as it explores a potential regenerative strategy that addresses mechanisms of skin aging, which is a fundamental aspect of longevity research.

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