Ovarian function is required for functional recovery of muscle by human ESC-derived mesenchymal progenitor cells in postmenopausal sarcopenic mice.

Dong Seok Jeong, Seongjun Park, Jeoung Eun Lee, Minjeong Kwak, Geon U Lee, Eunho Cha, Junghyun Jo, Dong Ryul Lee

Department of Biomedical Science, College of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.Department of Biomedical Science, College of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea. · pubmed

Paper

Abstract

In postmenopausal women, ovarian function decreases rapidly and is accompanied by senescence-related changes in skeletal muscle. Administration of human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs) influenced the functional maintenance of perimenopausal ovaries in female mice.

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Research summary

The paper claims that ovarian function is necessary for the recovery of muscle function through the use of human embryonic stem cell-derived mesenchymal progenitor cells in postmenopausal mice. This research addresses the relationship between ovarian function and muscle health in the context of aging, which is relevant to understanding and potentially mitigating age-related decline.

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