Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure.

Francesco Paolo Ruberto, Chang Jie Mick Lee, Matthew Ackers-Johnson, Pooja Sridharan, Vartika Khanchandani, Lik Hang Wu, Ling Xuan Goh, Tuan Danh Anh Luu, Leroy Sivappiragasam Pakkiri, Isabelle Bonne, Thong Beng Lu, Daniel J Buss, Tell Lovelace, Vivek Subramanian, Erielle Villanueva, Yang Hu, Prasanna Vidyasekar, Rijan Gurung, Jie Min Lee, Wai Khang Yong, Zhe Li, Dennis Kappei, Lena Ho, Chester Lee Drum, Roger S Y Foo

Cardiovascular Metabolic Disease Translational Research Programme, National University Health System, Singapore (F.P.R., C.J.M.L., M.A.-J., L.H.W., T.D.A.L., L.S.P., Y.H., P.V., R.G., C.L.D., R.S.Y.F.).Cardiovascular Metabolic Disease Translational Research Programme, National University Health System, Singapore (F.P.R., C.J.M.L., M.A.-J., L.H.W., T.D.A.L., L.S.P., Y.H., P.V., R.G., C.L.D., R.S.Y.F.). · pubmed

Paper

Abstract

Heart failure is a leading cause of morbidity and mortality worldwide, particularly among the growing elderly population. In degenerative aging and autoimmune diseases, the cytoplasmic leak of mitochondrial DNA, resulting from mitochondrial cristae compromise, triggers persistent low-grade cellular inflammation through activation of the cGAS (cyclic GMP [guanosine monophosphate]-AMP [adenosine monophosphate] synthase)-STING (stimulator of interferon genes) pathway and the IFN-I (type I interferon) response. However, how and whether mitochondrial architectural components and cardiomyocyte inflammation drive cardiac aging and failure are not yet well understood.

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Research summary

Loss of STMP1 leads to mitochondrial cristae disruption, which triggers cellular inflammation and contributes to heart failure. This paper is relevant as it explores the mechanisms underlying mitochondrial dysfunction and inflammation, which are key factors in the aging process and age-related diseases.

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