Trimethylamine N-oxide drives cardiac aging by activating NLRP3-mediated pyroptosis.

Zhaoxu Qiu, Huaxing Zhang, Bo Tan, Qian Chen, Huizi Gao, Yuhan Yao, Yangxuan Peng, Hongmei Xue, Qi Guo, Danyang Tian, Lin Xiao, Xu Teng, Yanzhuo Ma, Yuming Wu, Sheng Jin

Department of Physiology, Hebei Medical University, 050017, Hebei, China.Department of Physiology, Hebei Medical University, 050017, Hebei, China. · pubmed

Paper

Abstract

The present study was aimed to investigate whether trimethylamine N-oxide (TMAO) contributed to cardiac aging and to explore the underlying mechanism.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Trimethylamine N-oxide (TMAO) contributes to cardiac aging through the activation of NLRP3-mediated pyroptosis. This study addresses a potential mechanism underlying cardiac aging, which is a significant aspect of the aging process and could inform strategies for longevity.

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