Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6.

Selina Stahl, Hanna Widmaier, Vadim Sakk, Kodandaramireddy Nalapareddy, Ann-Kathrin Kissmann, Frank Rosenau, Medhanie A Mulaw, David B Haslam, Hartmut Geiger

Institute of Molecular Medicine, Ulm University, Ulm, Baden-Württemberg, 89081, Germany. · pubmed

Paper

Abstract

Age-associated dysregulation of the gut microbiota is a hallmark of aging and has been linked to multiple age-related diseases, yet upstream host factors driving these changes remain incompletely defined. Extensive bidirectional crosstalk between gut microbiota and mucosal immunity has been described. Aging is accompanied by a progressive decline in immune function, collectively termed aging-associated immune remodeling (AAIR). AAIR encompasses widespread compositional and functional changes that impair an effective response to pathogens, vaccines, and tissue damage. We examined whether AAIR is an upstream host factor influencing the composition of the microbiome upon aging.

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Research summary

The paper claims that aging-associated immune remodeling (AAIR) influences the composition of the gut microbiome. This research is relevant as it explores the interplay between immune system aging and microbiome changes, which could provide insights into the underlying mechanisms of aging and age-related diseases.

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