Immunological consequences of senescence in physiology and pathology.
Abstract
Cellular senescence is a sublethal stress response characterized by a durable cell-cycle arrest and the acquisition of a complex secretory program known as the senescence-associated secretory phenotype (SASP), which can profoundly influence local and systemic immunity. In physiological contexts-including embryonic development, tissue repair, and acute tumour suppression-senescent cells coordinate the recruitment and activation of immune cells, enabling their timely immune-mediated clearance and facilitating tissue remodelling and restoration of homeostasis. However, during aging and chronic disease, immune surveillance mechanisms frequently become compromised, allowing senescent cells to accumulate and persist within tissues.
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Research summary
The paper claims that cellular senescence influences immune responses in both physiological and pathological contexts. This research is relevant as it addresses the role of senescence in aging and its implications for immune function, which are critical for understanding the mechanisms underlying longevity and age-related diseases.
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