Circulating CD38 shows stronger association with incident heart failure in women despite lower levels: sex differences and kidney-function context.

Richard Mprah, Jeremiah Ong'Achwa Machuki, Prosperl Ivette Wowui, Diana Chulu, Yixuan Lei, Anastasia Wemaatu Lamawura Kanoseh, Manuella Quaye, Parfait Botolo Sakava, Simon Kumah Yalley, Joshua Nii Yemo Quarshie, Saffia Shaheen, Tao Dong, Hong Sun

Department of Physiology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China.Department of Physiology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China. · pubmed

Paper

Abstract

CD38, an NADase implicated in aging and metabolic stress, promotes cardiac dysfunction via NAD⁺ depletion. Whether circulating CD38 is associated with incident heart failure (HF), whether this association differs by sex, and how it relates to kidney-function context remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Circulating CD38 is associated with incident heart failure in women, highlighting sex differences and kidney-function context. The study addresses a potential mechanism (CD38's role in NAD⁺ depletion) that could link metabolic stress and cardiac dysfunction to aging processes.

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