Aging restricts maturation of CXCL13

Nathan A Bracey, Casey Beppler, Tatjana Bilich, Adrienne H Long, Elsa Sola, Aviv Barak, Timothy J Few-Cooper, Azam Mohsin, Vishnu Shankar, Vamsee Mallajosyula, Lilit Kamalyan, Robson Capasso, Shai S Shen-Orr, Mark M Davis

Department of Medicine, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N 1N4, Canada; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA. · pubmed

Paper

Abstract

A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear. CXCL13 is a chemokine that shapes germinal center (GC) organization, but the regulation of human-specific CXCL13

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that aging restricts the maturation of CXCL13, which is involved in the organization of germinal centers and antibody responses. This research is relevant as it explores the mechanisms underlying immune decline with aging, potentially addressing root causes of age-related immune dysfunction.

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