Effects of adiposity, insulin resistance, and inflammation on cardiometabolic multimorbidity: insights from interaction analyses and metabolic phenotyping in the China health and retirement longitudinal study 2011-2018.

Lili You, Wenbo Zhao, Meiguang Zheng, Xiaosi Hong, Meng Ren, Wenpeng Li

The Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.The Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. · pubmed

Paper

Abstract

Cardiometabolic multimorbidity (CMM) burdens aging populations. Obesity drives CMM via insulin resistance and inflammation, but their nonlinear and combined effects remain unclear. We elucidated how these factors contribute to CMM incidence.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the combined effects of adiposity, insulin resistance, and inflammation on the incidence of cardiometabolic multimorbidity. This research is relevant as it addresses factors contributing to age-related diseases and their underlying mechanisms, which are crucial for understanding and potentially mitigating the effects of aging.

Author of this paper? Send a correction.