Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens in the ageing brain.

Massimiliano Facca, Claudia Tarricone, Anna Ridolfo, Maurizio Corbetta, Andrei G Vlassenko, Manu S Goyal, Alessandra Bertoldo

Padova Neuroscience Center (PNC), University of Padova (Unipd), Padova, Italy. [email protected] Neuroscience Center (PNC), University of Padova (Unipd), Padova, Italy. [email protected]. · pubmed

Paper

Abstract

Cerebral glucose metabolism and cortical morphology are known to undergo significant changes across the lifespan, yet their network-level coordination remains poorly understood. This study aimed to investigate whether individual-level metabolic connectivity (MC) reflects underlying inter-areal morphometric similarity, and to determine how this metabolic-morphometric coupling evolves across the adult lifespan.

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Research summary

The paper claims that individual-level metabolic connectivity reflects inter-areal morphometric similarity and that this coupling evolves with age. This research is relevant as it explores the relationship between metabolic processes and brain morphology in the context of aging, contributing to the understanding of age-related changes in brain function and structure.

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