Transient perinuclear actin rings prevent cell aging and apoptosis via nuclear mechanical protection.

Haoxiang Yang, Houbo Sun, Junhui Zhang, Hao Wu, Hao Liu, Jinghao Shen, Weihao Wang, Huan Chen, Runjie Nie, Yating Zhu, Kailong Qiu, Dan Liang, Hongyuan Jiang

Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China; CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230026, Anhui, China.Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China; CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230026, Anhui, China. · pubmed

Paper

Abstract

Epithelial tissues in vivo are often subjected to the challenge of mechanical forces and osmotic shock. However, how epithelial cells prevent DNA damage and reduce aging and apoptosis in the presence of these intense external stimuli remains unclear. Here, we found a reversible perinuclear actin ring can be assembled after rapid and significant hypotonic shock or mechanical forces. Combining experiments and simulations, we demonstrate it is merely a transient response of actin network that is regulated by Ca

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Research summary

The paper claims that transient perinuclear actin rings can prevent cell aging and apoptosis through nuclear mechanical protection. This research addresses mechanisms that may contribute to cellular aging and apoptosis, which are central to understanding longevity and age-related cellular health.

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