Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.

Jennifer A Kurtz, K Michelle Singleton, Ecaterina Vasenina, Ralf Jäger, Drew Gonzalez, Antonella Schwarz, Jonathan Howard, Jose Antonio

Sports Nutrition and Performance Laboratory, Division of Kinesiology, University of Wyoming, Laramie, WY, USA. [email protected] Nutrition and Performance Laboratory, Division of Kinesiology, University of Wyoming, Laramie, WY, USA. [email protected]. · pubmed

Paper

Abstract

Aging is marked by progressive physiological decline driven by chronic inflammation, mitochondrial dysfunction, and impaired metabolic and musculoskeletal resilience. As the global population ages, dietary supplements have gained attention as potential tools to support healthy longevity. This review summarizes current evidence on nutritional compounds that target aging-related pathways, focusing on interventions that influence mitochondrial health, cognitive performance, immune function, metabolic regulation, and maintenance of muscle mass in older adults. Thirty-two human studies were identified through PubMed, Scopus, and Web of Science.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Targeted nutritional interventions can influence aging-related physiological pathways to support healthy longevity. The paper is relevant as it addresses nutritional strategies that may mitigate the root causes of aging, rather than merely treating age-related symptoms.

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