From in vitro to in vivo: hypoxia attenuates replicative senescence and preserves therapeutic activity in long-term passaged human umbilical cord-derived mesenchymal stem cells.

Chenxi Jia, Ze Lin, Tianrui Zhang, Lingbin He, Yueyang Li, Jianhong Li, Xinyi Li, Yuan Zhang, Bozhi Cai, Muping Zou, Libiao Wu, Xutao Zhao, Chunhong Ren, Xin Zhang

Laboratory of Molecular Cardiology, The First Affiliated Hospital of Shantou University Medical College, 57Th Changping Road, Shantou, 515041, Guangdong Province, People's Republic of China. · pubmed

Paper

Abstract

Mesenchymal stem cells (MSCs) hold great potential for regenerative medicine and tissue engineering. However, their clinical use is limited by low in vivo availability and rapid senescence during ex vivo expansion, posing a major challenge for scaled production. Growing evidence indicates that microenvironmental oxygen tension critically regulates MSCs fate. This study aims to systematically evaluate how different oxygen tensions modulate MSCs aging and function, providing evidence to optimize MSCs expansion protocols for clinical applications.

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Research summary

The paper claims that hypoxia can attenuate replicative senescence and preserve the therapeutic activity of long-term passaged human umbilical cord-derived mesenchymal stem cells. This research is relevant as it addresses the mechanisms of cellular aging and seeks to improve the longevity and functionality of stem cells, which could have implications for regenerative medicine and age-related therapies.

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