Suppression of senescent metabolism of adipose tissue by rebalancing mitochondrial homeostasis via a selective drug delivery system.

Liwei Wang, Kaicheng Xu, Ziye Guo, Xiaoyong Wu, Di Wang, Liang Chen, Donghua Huang, Kaile Wu, Yubin Zhao, Minjun Yao, Liming Zheng, Xiaobo Yang, Chenyi Ye, Wushi Cui, Wanli Li, An Liu, Mao Zhang, Jianbin Xu

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China. · pubmed

Paper

Abstract

Aging is characterized by a progressive decline in physiological function. Among various organs, adipose tissues play an important regulator of systemic metabolism and energy homeostasis. Age-associated alterations in adipose tissue are closely linked to organismal aging. Targeting senescent adipose tissue has therefore emerged as a potential strategy for mitigating age-related dysfunction. The purpose of this study was to develop and evaluate a selective drug delivery system for anti-aging therapy.

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Research summary

The paper claims to develop a selective drug delivery system that targets senescent adipose tissue to mitigate age-related dysfunction. This research is relevant as it addresses the underlying mechanisms of aging by focusing on senescent cells in adipose tissue, which are known to contribute to systemic metabolic decline associated with aging.

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