Exercise attenuates obesity-related cognitive and sleep-circadian dysfunctions by attenuating neuroinflammation via JAK/STAT in sex and age specific manner.

Archana Yadav, Morgan Barkley, John C Watson, Dev Patel, Andrew M Pickering, Girish C Melkani

Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. · pubmed

Paper

Abstract

Obesity including genetic obesity accelerates age-related cognitive decline and disrupts circadian regulation, increasing the risk of neurodegenerative disorders. These effects are mediated in part by metabolic dysregulation, neuroinflammation, and altered sleep-circadian cycles, yet the molecular and lifestyle factors that modify obesity-associated brain dysfunction remain poorly defined.

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Research summary

Exercise mitigates obesity-related cognitive decline and sleep-circadian dysfunction through neuroinflammation pathways. The paper addresses the underlying mechanisms of neuroinflammation and cognitive decline associated with obesity, which are critical factors in the aging process and longevity research.

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