Therapeutic targeting of DNA repair pathway dysregulation in aging, cancer, and neurodegeneration.

Vipin Kumar, Mohmmad Kashif, Vivek Singh, Rahul Singh Rawat, Aamir Khan, Gautam Chandra Sarkar, Misba Majood

DNA Replication and Cell Cycle Laboratory, National Institute of Immunology, New Delhi, India.DNA Replication and Cell Cycle Laboratory, National Institute of Immunology, New Delhi, India. · pubmed

Paper

Abstract

Genome maintenance is increasingly recognized as a shared vulnerability across aging, cancer, and neurodegeneration, yet the therapeutic implications of pathway-specific dysregulation of DNA repair remain incompletely defined.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that targeting dysregulated DNA repair pathways can provide therapeutic benefits in aging, cancer, and neurodegeneration. This research addresses the underlying mechanisms of aging and their implications for age-related diseases, making it relevant to longevity studies.

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