Host transcriptional signatures associated with microbial sequence signals reveal age-related decline in intestinal homeostasis.

Oluwamayowa S Akinsuyi, Amanda Ojeda, Jessica Xhumari, Jarrod V Ruggles, Anderson Santos de Freitas, Luiz F W Roesch

Institute of Food and Agriculture, Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.Institute of Food and Agriculture, Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA. · pubmed

Paper

Abstract

To characterize age-associated alterations in intestinal barrier homeostasis by integrating host transcriptomic profiles and mucosa-associated microbial sequence signals recovered from human colonic biopsy RNA-seq datasets.

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Research summary

The paper claims that age-related alterations in intestinal barrier homeostasis can be characterized by integrating host transcriptomic profiles and microbial sequence signals. This research is relevant as it addresses the underlying mechanisms of aging by exploring how microbial interactions and host responses contribute to age-related decline in intestinal health, which is a critical aspect of overall longevity.

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