Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.

Yunqiao Zhou, Jian Huang, Xinyi Chen, Leqin Xu, Fan Zhang, Chunxiao Bai, Jiju Yang, Fangyang Fan, Yuquan Wang, Bixuan Fang, Tian Wang, Junhao Li, Xiaohong Mu, Jinyu Li

Orthopedics Section 1, Dongzhimen Hospital of Beijing University of Chinese Medicine, No. 5 Haiyuncang Hutong, Dongcheng District, Beijing, 100700, China.Orthopedics Section 1, Dongzhimen Hospital of Beijing University of Chinese Medicine, No. 5 Haiyuncang Hutong, Dongcheng District, Beijing, 100700, China. · pubmed

Paper

Abstract

The rising co-occurrence of cardiometabolic diseases and musculoskeletal degeneration poses a critical challenge to healthy aging, yet the shared biological mechanisms underlying this multimorbidity remain poorly defined. This study aimed to establish an integrative clinical-genetic framework to elucidate the common frailty factor, the 'F' factor, that captures the systemic vulnerability linking cardiometabolic multimorbidity (CMM) and musculoskeletal aging.

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Research summary

The paper proposes a genetic-clinical framework to understand the 'F' factor linking cardiometabolic multimorbidity and musculoskeletal aging. This research addresses the underlying mechanisms of aging-related diseases, which is crucial for developing strategies to promote healthy longevity.

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