Identification and evaluation of citrus peel-derived polymethoxyflavonoids as natural SIRT1 activators.

Jung Ko, Dwina Juliana Warman, Peng Lu, Shiho Saito, Nana Sato, Ken Okamoto, Hideaki Itoh, Michio Suzuki, Hisanori Kato, Suguru Okuda, Koji Nagata

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. · pubmed

Paper

Abstract

Sirtuin 1 (SIRT1), an NAD

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Research summary

The study identifies specific polymethoxyflavonoids from citrus peel that activate SIRT1, a protein linked to aging pathways, representing an incremental advance in natural product screening for longevity targets. This work is relevant because SIRT1 activation is a direct mechanistic intervention in fundamental aging processes, although the use of natural extracts often yields modest effect sizes compared to synthetic small molecules.

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