Aging mechanisms and rejuvenation strategies for hematopoietic stem cells.
Abstract
Hematopoietic stem cells (HSCs) transition through different functional states throughout life from emergence and expansion in the fetus, homeostasis maintenance in adulthood, and progressive functional decline with age. Aged HSCs are characterized by increased phenotypic number, decreased self-renewal and long-term reconstitution capacity, myeloid-biased differentiation, and clonal hematopoiesis. In this review, we summarize the life cycle of HSCs, integrate recent advances in understanding the cell-intrinsic and extrinsic mechanisms that drive HSC aging, and highlight innovative rejuvenation strategies that could be harnessed to delay HSC and systemic aging.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses the mechanisms of aging in hematopoietic stem cells and explores rejuvenation strategies to mitigate these effects. This research is relevant as it addresses the underlying biological processes of aging and potential interventions to enhance longevity.
Author of this paper? Send a correction.