Inhibiting the Hif-1α-Drp1 axis alleviates mitochondrial dysfunction and reduces senescence-like changes in myocardial tissue after acute myocardial infarction.

Peng Yang, Yiheng Yang, Xiao Huang, Hongmin Zhu, Yuliang Zhan, Xinyong Cai, Zhenzhong Zheng, Qingshan Tian

Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China.Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China. · pubmed

Paper

Abstract

Cellular senescence is a significant pathological process in acute myocardial infarction (AMI), yet its upstream regulatory mechanisms remain unclear. This study reveals that the HIF-1α /Drp1 signaling axis serves as a critical link between hypoxia and senescence-like changes in myocardial tissue by disrupting mitochondrial homeostasis.

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Research summary

Inhibiting the HIF-1α-Drp1 axis can alleviate mitochondrial dysfunction and reduce senescence-like changes in myocardial tissue after acute myocardial infarction. This research addresses a potential upstream mechanism of cellular senescence, which is a key factor in aging and age-related diseases, thus contributing to the understanding of longevity.

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