Psychosis as a multisystem disorder of aberrant aging.

Rachel Upthegrove, Amalie C M Couch, Antonio de Marvao, Benjamin I Perry, Fabiana Corsi-Zuelli, Jack Rogers, Lahiru Handunnetthi, Nicholas M Barnes, Nikolaos Koutsouleris, Paris A Lalousis, Toby Pillinger, Zachary Freyberg

Department of Psychiatry, University of Oxford, Oxford, UK. [email protected]. · pubmed

Paper

Abstract

Psychotic disorders, including schizophrenia and affective psychosis, affect ~3% of the population and typically emerge in early adulthood. Cardiometabolic disease accounts for much of the 20-year life-expectancy gap in psychosis. Evidence indicates potentially causal processes, often seen in aging, act within and beyond the brain, and before the onset of treatment; these include inflammation, metabolic and mitochondrial dysfunction. Here we synthesize evidence and propose a framework that proposes psychosis as a multisystem disorder of accelerated aging, and outline implications for aging-targeted interventions.

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Research summary

The paper proposes that psychosis is a multisystem disorder characterized by accelerated aging processes. This research is relevant as it explores the underlying mechanisms of psychosis that may relate to aging, potentially informing interventions that target aging-related pathways.

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