A taxifolin-zinc nanozyme with SOD-like activity attenuates oxidative-stress-induced senescence and extends lifespan in C. elegans.

Xinru Tang, Fengxian Luo, Tao Chen, Xiaoxiao Zhou, Shumeng Hu, Xiaochen Chen, Xuesong Chi, Qingping Shi, Aixuan Lin, Bing Cui, Jiangning Hu

SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China.SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China. · pubmed

Paper

Abstract

Oxidative stress is a key driver of cellular senescence and functional decline. However, many natural polyphenols have limited bioavailability because they are difficult to formulate into stable systems. Here, we report a polyphenol-metal coordination nanozyme prepared by coordinating zinc with taxifolin and using L-arginine to regulate assembly. The resulting Tax-Zn nanozyme formed a well-dispersed nanoscale system with an average hydrodynamic diameter of 57.53 nm. Functionally, the nanozyme exhibited broad antioxidant capacity in several assays and showed slightly stronger activity than Tax in selected assays. In MEFs, Tax-Zn nanozyme showed low cytotoxicity and markedly suppressed intracellular ROS under H

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Research summary

The paper claims that a taxifolin-zinc nanozyme with SOD-like activity attenuates oxidative-stress-induced senescence and extends lifespan in C. elegans. This is relevant because it directly addresses the oxidative stress hypothesis of aging and demonstrates a functional lifespan extension in a model organism, although the use of a specific nanozyme formulation represents an incremental advance in antioxidant delivery rather than a fundamental breakthrough in aging biology.

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