Mitochondria-lysosome coupling contributes to lysosome acidification and aging.

Qingqing Liu, Seungmin Yoo, Zhixin A Zhang, Liying Li, Hetian Su, Lingraj Vannur, Alexandra C Wooldredge, Jun-Wei B Hughes, Pierre-Yves Desprez, Nan Hao, Gordon Lithgow, Julie K Andersen, Malene Hansen, Judith Campisi, Chuankai Zhou

Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA. · pubmed

Paper

Abstract

Nearly all cellular processes are pH dependent. The acidic pH inside the lysosome (vacuole in yeast) is essential for cellular content degradation, signaling, and autophagy. Defects in lysosome/vacuole acidification are a conserved hallmark of aging and age-related diseases. Traditionally, the lysosome/vacuole is thought to import free protons (H⁺) from the surrounding neutral cytosol. Here, we uncovered a conserved lysosome/vacuole acidification mechanism from yeast to human involving lysosomal/vacuolar uptake of H

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Research summary

The paper claims that a conserved mechanism of lysosome/vacuole acidification involving mitochondrial coupling is crucial for cellular function and aging. This research addresses a fundamental aspect of cellular aging and the mechanisms that contribute to age-related decline, making it relevant to longevity studies.

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