Reproductive aging drives deterministic microbiota assembly to mitigate uterine oxidative phosphorylation impairment via spermidine production in laying hens.

Dong Dai, Cheng Long, Kaixuan Ma, Wenchang Ma, Pengzu Wang, Guanghai Qi, Zhigang Zhou, Jing Wang

Laboratory of Quality and Safety Risk Assessment for Animal Products On Feed Hazards (Beijing) of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.Laboratory of Quality and Safety Risk Assessment for Animal Products On Feed Hazards (Beijing) of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China. · pubmed

Paper

Abstract

Reproductive aging represents a critical physiological bottleneck characterized by a progressive decline in tissue homeostasis and physiological function. While the gut microbiota is known to shift during host aging, the ecological forces governing the assembly of the reproductive microbiota and its functional feedback on uterine homeostasis remain poorly understood.

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Research summary

Reproductive aging drives changes in the gut microbiota that may help mitigate oxidative stress in the uterus through spermidine production. This research explores mechanisms related to aging and homeostasis, contributing to the understanding of reproductive aging and its implications for longevity.

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