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RESEARCH PAPER / 2026-05-28

Genetic and phenotypic associations of social isolation and loneliness with sarcopenia.

Xin Xu, Haobin Zhang, Fengshi Jing, Yawei Guo, Qingsong Chang, Tianyu Gao, Zhongzhi Xu

School of Public Health, Sun Yat-sen University, Guangzhou, China.School of Public Health, Sun Yat-sen University, Guangzhou, China. · pubmed

Abstract

Social isolation and loneliness are recognized risk factors for adverse aging outcomes, but their effects on sarcopenia remain understudied. This study investigated the independent and combined effects of social isolation and loneliness on the risk of incident sarcopenia in two large prospective cohorts: CHARLS (

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that social isolation and loneliness independently and combined increase the risk of incident sarcopenia. This research is relevant as it explores psychosocial factors that may contribute to age-related decline, specifically sarcopenia, which is a significant concern in the context of aging and longevity.

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