Multi-omics pleiotropic association analyses reveal functionally relevant genes and druggable pathways for ovarian aging.

Xuan Lian, Shuang Song, Chen Lou, Ming Zhu, Yan Li, Wenjian Li, Xintong Jiang, Guiquan Wang, Haiyan Yang, Lin Wang, Liying He, Yunlong Ma, Xi Dong, Yijie Chen, Hsun-Ming Chang, Wencheng Zhu, Jia Wang, Yang Yu, Yang Wu, Yue Zhao, Liangshan Mu

Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China. · pubmed

Paper

Abstract

Ovarian aging, marked by the gradual decline in both the number and quality of oocytes, significantly impacts women's reproductive lifespan and overall health. However, the biological mechanisms driving ovarian aging remain poorly understood and current treatment strategies are limited.

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Research summary

The paper claims to identify functionally relevant genes and druggable pathways associated with ovarian aging. This research addresses the biological mechanisms of ovarian aging, which is a fundamental aspect of reproductive aging and has implications for overall longevity and health in women.

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