Mitochondria-ER contact sites (MERCS) in the cell cycle: molecular architecture and functional remodeling across cellular states.

Eduardo Silva-Pavez, Bruno Torres-Gonzalez, Michelle Sotomayor, Benjamín Cartes-Saavedra, Dorian V Ziegler, Yessia Hidalgo-Fadic, Ulises Ahumada-Castro

Facultad de Odontología, Universidad San Sebastián, Bellavista 7, Recoleta, Santiago, Chile. · pubmed

Paper

Abstract

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are nanoscopic, dynamic platforms integrating metabolism, signaling, and stress responses to regulate cell fate. These nanoscopic interfaces remodel continuously to meet the demands of proliferating, quiescent, and senescent cells. We synthesize evidence that MERCS actively coordinate local Ca

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Research summary

MERCS actively coordinate local calcium signaling and metabolic processes to influence cell fate across different cellular states. This research is relevant as it explores the molecular mechanisms that could underlie cellular aging and the transition between different states of cellular health, which are critical for understanding longevity and age-related cellular dysfunction.

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