Repeated head impacts establish a senescent cranial bone marrow niche that impairs brain metabolism.

Patrick J Devlin, Romeesa Khan, Trang H Do, Bryce E West, Janelle M Korf, Gary U Guzman, John Ahn, Alexander Saltzman, Antrix Jain, Chunfeng Tan, Rene Flores, Micheal E Maniskas, Sean P Marrelli, Anna Malovannaya, Erica Underwood, Rodney M Ritzel

Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA. · pubmed

Paper

Abstract

Traumatic brain injury (TBI) of any severity is associated with long-term systemic inflammation and increased risk of peripheral comorbidities, yet the mechanisms driving immune dysregulation and accelerated aging after repeated sub-concussive head impacts remain poorly defined. Here, we investigated the acute and chronic effects of repetitive head impacts (RHI) on distal and proximal bone marrow compartments in the femur and calvaria, respectively.

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Research summary

Repeated head impacts lead to a senescent cranial bone marrow niche that impairs brain metabolism. This study explores mechanisms of immune dysregulation and aging related to traumatic brain injury, which are pertinent to understanding the root causes of aging and age-related diseases.

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