Phlorizin activates BMP10 to attenuate atherosclerosis by inhibiting vascular endothelial senescence and inflammation in Apoe
Abstract
Atherosclerosis is a chronic inflammatory vascular disease characterized by lipid deposition, endothelial dysfunction, and cellular senescence, posing a significant threat to the cardiovascular system. As demonstrated in previous studies, phlorizin has been shown to have anti-atherosclerotic effects. However, the precise molecular mechanisms by which this occurs remain to be elucidated. This study aimed to investigate the preventive effect of phlorizin on atherosclerosis and elucidate the molecular network mediated by bone morphogenetic protein 10 (BMP10). A total of 40 eight-week-old Apoe
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Research summary
Phlorizin activates BMP10 to inhibit vascular endothelial senescence and inflammation, thereby attenuating atherosclerosis. The study addresses mechanisms that could contribute to vascular aging and age-related diseases, making it relevant to longevity research.
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