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RESEARCH PAPER / 2026-05-27

Beyond reproduction: The ovary as a systemic regulator of female health and aging.

Jennifer L Garrison

Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America.Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America. · pubmed

Abstract

Classifying ovaries solely as reproductive organs has obscured their role as systemic regulators of female physiology. This Perspective makes the case that ovarian aging is a primary determinant of healthspan and belongs at the center of geroscience.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Ovarian aging is proposed as a primary determinant of healthspan and a central focus in geroscience. This paper is relevant as it addresses the systemic role of ovaries in female health and aging, suggesting that understanding ovarian aging could lead to insights into the root causes of aging and healthspan extension.

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