HucMSC-mediated stromal metabolic reprogramming in reactivating aged ovaries: a single-cell transcriptomic perspective.

Ying-Yi Zhang, Yuqing Mei, Weijie Yang, Hanjing Zhou, Yan Zhou, Yingyan Chen, Yi Zhang, Jianmin Chen, Jiamin Jin, Xiaomei Tong, Libing Shi, Dong Huang, Guoji Guo, Yin-Li Zhang, Songying Zhang

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China. · pubmed

Paper

Abstract

Aging-induced decline in ovarian function and oocyte quality contributes to female infertility. However, the mechanisms underlying human umbilical cord-derived mesenchymal stem cell (HucMSC)-mediated rejuvenation of aged ovaries remain poorly understood. This study aimed to systematically investigate whether and how HucMSCs restore ovarian function and oocyte quality and elucidate the potential pathways involved.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that HucMSCs can restore ovarian function and oocyte quality in aged ovaries through metabolic reprogramming. This research is relevant as it explores potential mechanisms for rejuvenating reproductive function, addressing a root cause of aging-related infertility.

Author of this paper? Send a correction.