Uncovering the initial response: Intra-mitochondrial surveillance activates the UPR

Asli Aras Taskin, Sahana Shankar, Carlotta Peselj, Annette Flotho, Maria Gomez-Fabra Gala, Daniel Poveda-Huertes, Lisa Myketin, Duygu Mutlu, Adinayarana Marada, Sebastian Schuck, Mandy Jeske, Sabrina Büttner, Marcin Luzarowski, Chris Meisinger, F-Nora Vögtle

Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany. · pubmed

Paper

Abstract

The mitochondrial unfolded protein response (UPR

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Research summary

The paper claims that intra-mitochondrial surveillance activates the UPR in response to stress. This research is relevant as it explores mechanisms related to mitochondrial function and stress responses, which are critical in understanding the aging process and potential interventions for age-related diseases.

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