Dual Effects of Nicotinamide on Aging-Related Arrhythmia: Protective at Low Dose, Proarrhythmic at Higher Doses.
Abstract
Cardiac arrhythmia and dysfunction increase with age and are closely associated with declining nicotinamide adenine dinucleotide levels. Nicotinamide, a critical nicotinamide adenine dinucleotide precursor, has shown protective effects in experimental models of aging-related cardiac diseases. However, its dose-dependent cardiac-specific adverse effects and underlying mechanisms warrant investigation.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
Nicotinamide has dual effects on aging-related arrhythmia, being protective at low doses and proarrhythmic at higher doses. The paper is relevant as it investigates the dose-dependent effects of a NAD+ precursor on cardiac health, which is crucial for understanding and potentially mitigating age-related cardiac dysfunction.
Author of this paper? Send a correction.