Geroprotection through modulation of heart rate variability, oxidative enzymes, tissue integrity, and gene expression by an Ayurvedic herbal formulation, Amalaki Rasayana.

Cheryl Rhea Lewis, Vasudha Devi, Dinesh Upadhya, Dhandapani Kuppuswamy, Rajshekhar Chinta, Shiny Jasphin, Souvik Dey, Neha Choudhari, Anandan E M

Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. · pubmed

Paper

Abstract

Aging is a multifactorial process involving cumulative cellular and organ deterioration, largely due to oxidative stress and disrupted homeostasis. These changes lead to increased susceptibility to age-related diseases. Amalaki Rasayana (AR), an ayurvedic formulation from the fruit of Phyllanthus emblica, is traditionally valued for its geroprotective, rejuvenating effects and preventive healthcare.

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Research summary

The paper claims that Amalaki Rasayana can modulate heart rate variability, oxidative enzymes, tissue integrity, and gene expression to provide geroprotection. This research is relevant as it explores a traditional herbal formulation's potential to address underlying mechanisms of aging and oxidative stress, which are critical factors in longevity and age-related diseases.

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