The gut-bone axis: microbial metabolism and nutritional interventions for bone health.
Abstract
Osteoporosis is a prevalent condition characterized by a rapid decline in bone mineral density and distorted microarchitecture, which leads to increased bone fragility. The gut microbiota and its metabolites play a crucial role in the development and progression of osteoporosis by influencing gut permeability, nutrient digestion and absorption, pH balance, and immune regulation. Nutritional interventions aimed at modulating gut microbiota, through postbiotics (butyrate), probiotics (
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Research summary
The paper claims that modulating gut microbiota through nutritional interventions can influence bone health and potentially mitigate osteoporosis. This research is relevant as it explores the gut-bone axis, which may address underlying mechanisms related to aging and bone density decline, contributing to longevity.
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