Mitochondrial-Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC-HET

Hoang Van M Nguyen, Finterly Hu, Evaniya Shakya, Chloe Fender, Kenneth Lee, Jason Schindler, Manuel Garcia-Jaramillo, Nagib Ahsan, Janet C Siebert, Sarah J Borengasser, Norman G Hord, Michael B Stout, Steven Austad, Arlan Richardson

Department of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA. · pubmed

Paper

Abstract

The effect of mitochondrial-haplotype (mt-haplotype) on aging was studied using a unique rat model (OKC-HET

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Research summary

The paper claims that mitochondrial-haplotype influences the plasma metabolome, lipidome, and proteome in a sex-specific manner. This research is relevant as it explores the role of mitochondrial genetics in biological processes that could be linked to aging mechanisms.

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