Calcitriol is involved in maintaining primordial follicle reserve through the inhibition of the PI3K/Akt signaling pathway.

Shuang Liu, Ye Chen, Hongwei Wei, Huiyu Liu, Weiyong Wang, Yanli Sun, Luchun Zhang, Sihui He, Xiaodan Zhang, Jingjie Li, Meijia Zhang

The Innovation Centre of Ministry of Education for Development and Diseases, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China. · pubmed

Paper

Abstract

In mammals, precise regulation of primordial follicle activation is essential for maintaining the female reproductive lifespan. In this study, we demonstrated that the vitamin D receptor (VDR) is expressed in both pre-granulosa cells and oocytes within primordial follicles of mice and humans.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Calcitriol plays a role in preserving the primordial follicle reserve by inhibiting the PI3K/Akt signaling pathway. This research is relevant as it explores mechanisms that could influence female reproductive aging and longevity.

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