A PUFA-rich diet increases endogenous genotoxic stress and mitochondrial DNA damage in mice.

Masatomi Shimizu, Ayako Daizo, Kenichi Kawada, Masayo Ikeda, Petr Grúz

Division of Medical Nutrition, Faculty of Healthcare, Tokyo Healthcare University, 3-11-3, Setagaya-Ku, Tokyo, 154-8568, Japan. [email protected] of Medical Nutrition, Faculty of Healthcare, Tokyo Healthcare University, 3-11-3, Setagaya-Ku, Tokyo, 154-8568, Japan. [email protected]. · pubmed

Paper

Abstract

Substitution of dietary saturated fat with seed oils highly enriched in n-6 polyunsaturated fatty acids (PUFAs) has been advocated as healthy strategy to offset elevated cholesterol levels. However, both n-6 as well as n-3 PUFAs, considered essential because vertebrates lack the enzymatic apparatus for their de novo synthesis, are the main source of endogenous DNA damage during the aging process due to their high oxidizability. The membrane pacemaker theory of aging is an extension to the oxidative theory of aging and postulates that higher PUFA content in membrane lipids determines the lifespan of different species.

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Research summary

A PUFA-rich diet increases endogenous genotoxic stress and mitochondrial DNA damage in mice. This paper is relevant as it explores the impact of dietary components on cellular damage and aging, potentially addressing root causes of aging through the lens of dietary influences on mitochondrial health.

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