Dendrobium nobile Lindl. Alkaloids promote longevity and stress resistance of Caenorhabditis elegans via DAF-16 and skn-1.

Jing Liu, Jingxin Zhang, Di Cui, Yunyan Xu, Bo Liu

Department of Pharmacy, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; College of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China. · pubmed

Paper

Abstract

This study aimed to explore the anti-aging effects and mechanisms of Dendrobium nobile Lindl. Alkaloids (DNLA) on Caenorhabditis elegans (C. elegans).

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Dendrobium nobile Lindl. Alkaloids extend the lifespan and stress resistance of C. elegans by activating the DAF-16 and SKN-1 transcription factors. This is a standard pharmacological screening study in a model organism that identifies a compound with lifespan-extending properties via known conserved pathways, representing an incremental addition to the field of geroprotection rather than a fundamental breakthrough.

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