Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts.

Xinyi Zhang, Jing Wang, Ying Zhou, Chenye Shen, Minjia Yuan, Qi Li, Wei Li

Shanghai Qiran Biotechnology Co., Ltd, Shanghai, PR China. · pubmed

Abstract

Skin photoaging induced by chronic ultraviolet B (UVB) exposure is primarily driven by oxidative stress. Emerging evidence suggests that ferroptosis contributes to UVB-induced skin damage. Sauchinone, a phenolic lignan derived from

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Sauchinone reduces UVB-induced photoaging by inhibiting oxidative stress and ferroptosis via the Keap1-Nrf2 pathway. The study addresses mechanisms of skin aging related to oxidative stress, which is a significant factor in the aging process.

Author of this paper? Send a correction.