Epigenetic age enhances eGFR-based prediction of all-cause mortality: A cross-cohort validation of a novel risk model.
Abstract
Chronic kidney disease and biological aging share overlapping mechanisms, but conventional risk models may not adequately capture their combined impact on mortality. This study aimed to determine whether integrating DNA methylation-based biological age (epigenetic age) with renal function estimates could enhance mortality risk prediction.
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Research summary
Integrating epigenetic age with eGFR improves mortality risk prediction. This research addresses the intersection of biological aging and chronic kidney disease, which is pertinent to understanding aging mechanisms and their impact on longevity.
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