Antioxidant Proline Carbon Dot-Composited Poly(L-methionine) Hydrogel Restores Mitophagy to Alleviate Cellular Senescence in Intervertebral Disc Degeneration.

Zongtai Liu, Qingzheng Zhang, Haochen Yao, Changfeng Fu, Yirong Sun, Jianxun Ding

Department of Spine Surgery, Center of Orthopedics, Jilin Engineering Research Center for Spine and Spinal Cord Injury, The First Hospital of Jilin University, Changchun, P. R. China. · pubmed

Paper

Abstract

The senescence of nucleus pulposus cells (NPCs) is a hallmark pathological feature of intervertebral disc degeneration. Senescent NPCs exhibit mitochondrial dysfunction and impaired mitophagy, thus compromising mitochondrial turnover and quality control. Current therapeutic strategies predominantly target external risk factors but do not restore mitophagy. In this study, a proline carbon dot-composited poly(L-methionine) (EG

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Research summary

The study claims that a proline carbon dot-composited poly(L-methionine) hydrogel can restore mitophagy in nucleus pulposus cells to alleviate cellular senescence in intervertebral disc degeneration. This research addresses the underlying mechanisms of cellular senescence and mitochondrial dysfunction, which are critical factors in the aging process and age-related degeneration.

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