Association between pace of aging estimated from blood DNA methylation and all-cause mortality: the HUNT study.

Yi-Qian Sun, Ilona Urbarova, Lin Jiang, Therese Haugdahl Nøst, Xiao-Mei Mai

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. [email protected]. · pubmed

Paper

Abstract

Epigenetic clocks, developed using blood DNA methylation data, can be used to estimate biological ages and pace of aging. We aimed to identify potential determinants of the pace of aging, estimated using blood DNA methylation, and to investigate the association between the pace of aging and all-cause mortality in a population-based Norwegian cohort with repeated DNA methylation measurements.

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Research summary

The paper claims that the pace of aging, as estimated from blood DNA methylation, is associated with all-cause mortality. This research is relevant as it investigates biological aging mechanisms and their implications for longevity and mortality, addressing fundamental aspects of aging rather than merely treating age-related diseases.

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