Selective elimination of amyloid-β-induced senescent neuroblastoma cells by Moringa oleifera leaf extract.

Nur Irlia Sofea Mohammad Zamani, Hamizah Shahirah Hamezah, Ahmed Mediani, Mizanurfakhri Ghazali, Muhammad Zulfiqah Sadikan, Faidruz Azura Jam

Faculty of Medicine, Manipal University College Malaysia (MUCM), Jalan Batu Hampar, Bukit Baru, Melaka, 75150, Malaysia. · pubmed

Paper

Abstract

Accumulation of senescent cells (SnCs) in the ageing brain contributes to Alzheimer's disease (AD) progression by secreting a senescence-associated secretory phenotype (SASP) that exacerbates neuroinflammation and neurodegeneration. Senolytic agents that selectively eliminate SnCs have emerged as a potential therapeutic strategy; however, safer natural alternatives remain underexplored. In this study, we aimed to investigate the senolytic potential of Moringa oleifera leaf extract (MOL) in an in vitro AD-senescence model using SH-SY5Y cells exposed to amyloid-β (Aβ

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Research summary

The paper claims that Moringa oleifera leaf extract can selectively eliminate amyloid-β-induced senescent neuroblastoma cells. This research is relevant as it explores a potential natural senolytic agent that may address the accumulation of senescent cells, which is a contributing factor to aging and age-related diseases like Alzheimer's.

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