Crosstalk between lipid metabolism and epigenetics in cellular senescence and age-related diseases.

Xiao Yu, Fanke Huang, Menghui Hou, Nan Wang, Qianhui Ma, Minghe Li, Chang Zhang, Haiying Zhang, Yingai Shi, Xu He

The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China. · pubmed

Paper

Abstract

Cellular senescence induced by internal and external stimuli features stable cell cycle arrest and SASP, closely linked to aging and various age-related diseases. It is accompanied by lipid metabolism disorders and epigenetic abnormalities, which interact closely to modulate senescence. This review summarizes their crosstalk in senescence and relevant diseases, aiming to offer new insights and therapeutic targets for alleviating cellular senescence and treating age-related diseases.

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Research summary

The paper discusses the interaction between lipid metabolism and epigenetics in cellular senescence, which are key factors in the aging process. This research is relevant as it addresses mechanisms that contribute to the root causes of aging and age-related diseases, potentially leading to therapeutic targets for longevity.

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