Integrated photoprotection and senescence modulation: A topical formulation counteracts cellular aging in human skin cells.

Iwona Rzeszutek, Anna Tomaszewska, Dominika Rumian, Magdalena Kulpa-Greszta, Anna Deręgowska, Jagoda Adamczyk-Grochala, Maria Romerowicz-Misielak, Tomasz Kostrzewa, Wioletta Barańska-Rybak, Magdalena Górska-Ponikowska

Interdiscyplinary Centre for Preclinical and Clinical Research, Faculty of Biotechnology, Collegium Medicum, University of Rzeszów, Werynia 2a, Kolbuszowa 36-100, Poland; Faculty of Biotechnology, Collegium Medicum, University of Rzeszów, Pigonia 1, Rzeszów 35-310, Poland. Electronic address: [email protected]. · pubmed

Paper

Abstract

Skin aging is driven by the accumulation of senescent cells that release a pro-inflammatory mediators, which collectively disrupt tissue homeostasis. Beside ultraviolet A (UVA) and ultraviolet B (UVB) radiation, high-energy visible blue-violet (HEV) light contributes to oxidative stress, mitochondrial dysfunction and premature keratinocyte senescence. A novel photoprotective topical formulation comprising hydroxyapatite, fermented oils, baicalin and crocin was developed to counteract these effects. This study evaluated its biological effect in human skin cell models under basal conditions, oxidative stress-induced premature senescence (SIPS) and HEV exposure.

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Research summary

The paper claims that a novel topical formulation can counteract cellular aging in human skin cells by modulating senescence and providing photoprotection. This research addresses the mechanisms of cellular aging and seeks to mitigate its effects, which is directly relevant to longevity studies.

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