DNA methylation-based estimator of blood telomere length (DNAmTL) outperforms qPCR-based telomere length in reflecting clinical and sociodemographic factors in people with HIV infection.

Andrés Esteban-Cantos, Javier Rodríguez-Centeno, Rocío Montejano, Julen Cadiñanos, Rosa de Miguel-Buckley, Lucía Gutiérrez-García, Cristina Marcelo-Calvo, Patricia Martínez-Martín, Jose I Bernardino, Alejandro de Gea-Grela, Alejandro Díez-Vidal, Carlos Oñoro, Berta Rodés, José R Arribas

HIV/AIDS and Infectious Diseases Research Group, Hospital Universitario La Paz-IdiPAZ, Paseo de La Castellana 261, 28046, Madrid, Spain. [email protected]. · pubmed

Paper

Abstract

Telomere length (TL) is a widely used biomarker of biological aging, and is shortened in people living with HIV (PWH) due to chronic inflammation and immune-activation. The DNA methylation-based estimator of TL (DNAmTL) has emerged as a promising alternative to classical TL measurements, but their comparative performance in PWH remains poorly characterized.

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Research summary

The paper claims that the DNA methylation-based estimator of telomere length (DNAmTL) is a more effective measure of telomere length in reflecting clinical and sociodemographic factors in people with HIV infection compared to traditional qPCR methods. This research is relevant as it explores a biomarker associated with biological aging and its implications in a specific population affected by chronic inflammation, contributing to the understanding of aging processes.

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