Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction.

Haobo Li, Xiao Xiao, Yirong Zhou, Yajing Zhang, Jiayi Kang, Zixun Yuan, Jiaqi He, Justin Guerra, Carolin Lerchenmüller, Kenneth B Margulies, Aaron D Aguirre, Jason D Roh, Anthony Rosenzweig

Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. · pubmed

Paper

Abstract

Ageing is accompanied by progressive microvascular dysfunction, a key determinant of organ performance and longevity. The molecular drivers of this process remain incompletely defined, and the mechanisms by which exercise counters vascular ageing are unclear. This study investigated whether exercise-regulated long noncoding RNAs (lncRNAs) contribute to microvascular ageing and age-related cardiac dysfunction.

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Research summary

The paper claims that exercise-regulated long noncoding RNAs contribute to microvascular ageing and age-related cardiac dysfunction. This research addresses mechanisms underlying microvascular dysfunction in aging, which is a key determinant of longevity and organ performance.

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